Dynamic bioprocessing and microfluidic transport control with smart magnetic nanoparticles in laminar-flow devices

Bioprocess microfluidics: applying microfluidic devices for bioprocessing

Scale-down approaches have long been applied in bioprocessing to resolve scale-up problems. Miniaturized bioreactors have thrived as a tool to obtain process relevant data during early-stage process development. Microfluidic devices are an attractive alternative in bioprocessing development due to the high degree of control over process variables afforded by the laminar flow, and the possibilit...

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Microfluidic devices have advanced cell studies by providing a dynamic fluidic environment on the scale of the cell for studying, manipulating, sorting and counting cells. However, manipulating the cell within the fluidic domain remains a challenge and requires complicated fabrication protocols for forming valves and electrodes, or demands specialty equipment like optical tweezers. Here, we dem...

Flow Focusing in Microfluidic Devices

This paper presents numerical analysis of the hydrodynamic flow focusing in rectangular microchannels. The low Reynolds number pressure driven flow in symmetric system of crossed channels with three inlets and one outlet is investigated. The numerical model is used to elucidate the origin of broadening of the focused flow sheet observed experimentally close to the side walls of the outlet chann...

Heat Transfer Enhancement and Entropy Generation of Nanofluids Laminar Convection in Microchannels with Flow Control Devices

The heat transfer enhancement and entropy generation of Al2O3-water nanofluids laminar convective flow in the microchannels with flow control devices (cylinder, rectangle, protrusion, and v-groove) were investigated in this research. The effects of the geometrical structure of the microchannel, nanofluids concentration φ(0%–3%), and Reynolds number Re (50–300) were comparatively studied by mean...

Magnetic Field-Based Microfluidic Devices